Scientists reveal mechanism behind evolution of brain folds regulated by ancient gene
Summary
Chinese scientists have identified an ancient gene, CCNB1IP1, and a regulatory sequence that help drive brain folding during evolution. Mouse experiments showed that adding the gene can trigger cortical folds and improve learning and memory.
Key Points
- A Chinese research team found that the ancient gene CCNB1IP1 is linked to the evolution of brain folds and is expressed at higher levels in species with folded brains.
- The team identified the regulatory sequence CRE1 as a key driver of CCNB1IP1 expression.
- Mouse knock-in experiments showed cortical folding structures and improved learning and memory.
- The findings, published in Nature Genetics, may help explain human brain evolution and neural development disorders.
