Scientists reveal how exercise protects brain from Alzheimer’s: Study
Summary
Researchers at UC San Francisco discovered that exercise triggers the liver to release an enzyme that reduces brain inflammation by restoring the blood-brain barrier, potentially protecting against Alzheimer's disease.
Key Points
- Exercise triggers the liver to release the enzyme GPLD1, which helps repair the blood-brain barrier.
- GPLD1 removes TNAP, a protein that accumulates in the blood-brain barrier and causes leakiness and inflammation with age.
- Reducing TNAP levels in older mice improved memory and reduced brain inflammation.
- The findings open new therapeutic avenues for Alzheimer's by targeting the blood-brain barrier rather than the brain directly.
